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\"image.png\"<\/p>\n

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\u708e\u75c7\u6027\u75bc\u75db\u7684\u672c\u8d28\u4e0d\u662f\u300c\u8eab\u4f53\u611f\u53d7\u5230\u4e86\u66f4\u5f3a\u7684\u523a\u6fc0\u300d\uff0c\u800c\u662f\u300c\u8eab\u4f53\u628a\u6b63\u5e38\u5f3a\u5ea6\u7684\u523a\u6fc0\uff0c\u5904\u7406\u6210\u4e86\u66f4\u5f3a\u70c8\u7684\u75bc\u300d\uff0c\u4fe1\u53f7\u88ab\u653e\u5927\u4e86\u3002<\/p>\n

\u90a3\u8c01\u8d1f\u8d23\u8c03\u4f4e\u8fd9\u4e2a\u9608\u503c\uff1f<\/p>\n

\n

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1935\u5e74\uff0c\u745e\u5178\u751f\u7406\u5b66\u5bb6\u51af\u00b7\u6b27\u62c9\u4ece\u7cbe\u6db2\u91cc\u5206\u79bb\u51fa\u4e00\u79cd\u7269\u8d28\uff0c\u4ee5\u4e3a\u5b83\u6765\u81ea\u524d\u5217\u817a\uff0c\u4e8e\u662f\u547d\u540d\u4e3a\u300c\u524d\u5217\u817a\u7d20\u300d\uff08prostaglandin\uff09\u3002<\/p>\n

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\u4f46\u540d\u5b57\u5c31\u8fd9\u4e48\u7559\u4e0b\u6765\u4e86\u3002<\/p>\n

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\u5b83\u4eec\u4e0d\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u800c\u662f\u5728\u5c40\u90e8\u53d1\u6325\u4f5c\u7528\u2014\u2014\u54ea\u91cc\u635f\u4f24\u4e86\uff0c\u54ea\u91cc\u5c31\u5408\u6210\u524d\u5217\u817a\u7d20\uff0c\u524d\u5217\u817a\u7d20\u5c31\u5728\u90a3\u4e2a\u5730\u65b9\u5de5\u4f5c\u3002<\/p>\n

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\u5e03\u6d1b\u82ac\u5c31\u662f\u5728\u8fd9\u91cc\u8d77\u4f5c\u7528\u3002<\/p>\n

\n

\u4e09\u3001COX\u9176\uff1a\u628a\u63d2\u5934\u62d4\u6389\u4e4b\u524d\uff0c\u5148\u627e\u5230\u63d2\u5934<\/h3>\n

\u82b1\u751f\u56db\u70ef\u9178\u53d8\u6210\u524d\u5217\u817a\u7d20\uff0c\u4e2d\u95f4\u9700\u8981\u4e00\u4e2a\u50ac\u5316\u9176\uff0c\u53eb\u73af\u6c27\u5408\u9176\uff0c\u82f1\u6587\u7f29\u5199COX\uff08cyclooxygenase\uff09\u3002<\/p>\n

COX\u9176\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u662f\u4e00\u4e2a\u5f62\u72b6\u7279\u6b8a\u7684\u758f\u6c34\u901a\u9053\u3002\u82b1\u751f\u56db\u70ef\u9178\u94bb\u8fdb\u8fd9\u4e2a\u901a\u9053\uff0c\u88ab\u6c27\u5316\u6210\u524d\u5217\u817a\u7d20\u524d\u4f53\uff0c\u7136\u540e\u4e00\u6b65\u6b65\u53d8\u6210\u5404\u79cd\u524d\u5217\u817a\u7d20\u3002<\/p>\n

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\u5e03\u6d1b\u82ac\u7684\u5206\u5b50\u5f62\u72b6\uff0c\u548c\u8fd9\u4e2a\u901a\u9053\u7684\u5165\u53e3\u9ad8\u5ea6\u5951\u5408\u3002<\/p>\n

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\n

\u56db\u3001\u4e3a\u4ec0\u4e48\u5e03\u6d1b\u82ac\u4f1a\u4f24\u80c3<\/h3>\n

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COX\u9176\u6709\u4e24\u79cd\u4e9a\u578b\uff1aCOX-1\u548cCOX-2\u3002<\/p>\n

COX-2\u662f\u300c\u5e94\u6fc0\u578b\u300d\u7684\u2014\u2014\u5e73\u65f6\u51e0\u4e4e\u4e0d\u8868\u8fbe\uff0c\u7ec4\u7ec7\u53d7\u635f\u65f6\u88ab\u5927\u91cf\u8bf1\u5bfc\u5408\u6210\uff0c\u4e13\u95e8\u8d1f\u8d23\u708e\u75c7\u53cd\u5e94\u91cc\u90a3\u4e9b\u524d\u5217\u817a\u7d20\u7684\u751f\u4ea7\u3002<\/p>\n

COX-1\u662f\u300c\u7ba1\u5bb6\u578b\u300d\u7684\u2014\u2014\u51e0\u4e4e\u6240\u6709\u7ec6\u80de\u90fd\u6301\u7eed\u4f4e\u6c34\u5e73\u8868\u8fbe\uff0c\u8d1f\u8d23\u7ef4\u6301\u6b63\u5e38\u751f\u7406\u529f\u80fd\uff0c\u6bd4\u5982\u4fdd\u62a4\u80c3\u9ecf\u819c\u3001\u8c03\u8282\u80be\u810f\u8840\u6d41\u3001\u5e2e\u52a9\u8840\u5c0f\u677f\u805a\u96c6\u3002<\/p>\n

\u5e03\u6d1b\u82ac\u8fd9\u628a\u300c\u6b6a\u94a5\u5319\u300d\uff0c\u63d2\u8fdbCOX-1\u548cCOX-2\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u4e24\u4e2a\u90fd\u80fd\u5835\u3002<\/p>\n

\u5b83\u5728\u538b\u5236\u708e\u75c7\u90e8\u4f4dCOX-2\u7684\u540c\u65f6\uff0c\u4e5f\u628a\u80c3\u9ecf\u819c\u91cc\u8d1f\u8d23\u4fdd\u62a4\u7684COX-1\u4e00\u5e76\u538b\u5236\u4e86\u3002<\/p>\n

\u80c3\u9ecf\u819c\u7684\u4fdd\u62a4\u5c42\uff0c\u9760COX-1\u5408\u6210\u7684\u524d\u5217\u817a\u7d20\u7ef4\u6301\u3002<\/p>\n

\u524d\u5217\u817a\u7d20\u88ab\u538b\u5236\uff0c\u9ecf\u6db2\u5206\u6ccc\u51cf\u5c11\uff0c\u80c3\u9178\u5c31\u76f4\u63a5\u63a5\u89e6\u9ecf\u819c\uff0c\u4e8e\u662f\u6709\u4e86\u300c\u5e03\u6d1b\u82ac\u4f24\u80c3\u300d\u7684\u95ee\u9898\u3002<\/p>\n

\u8fd9\u4e0d\u662f\u5e03\u6d1b\u82ac\u7684\u8bbe\u8ba1\u7f3a\u9677\uff0c\u662f\u5b83\u4f5c\u7528\u673a\u5236\u7684\u5fc5\u7136\u540e\u679c\u3002<\/p>\n

1990\u5e74\u4ee3\uff0c\u836f\u7406\u5b66\u5bb6\u8bd5\u56fe\u5f00\u53d1\u300c\u53ea\u5835COX-2\u3001\u4e0d\u78b0COX-1\u300d\u7684\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u4e5f\u5c31\u662f\u540e\u6765\u7684\u300c\u6614\u5e03\u7c7b\u300d\u836f\u7269\uff08\u5982\u585e\u6765\u6614\u5e03\uff09\u3002<\/p>\n

\u80c3\u786e\u5b9e\u597d\u591a\u4e86\uff0c\u4f46\u968f\u540e\u53d1\u73b0COX-2\u5728\u5fc3\u810f\u91cc\u4e5f\u6709\u6b63\u5e38\u751f\u7406\u529f\u80fd\u2014\u2014\u538b\u5236COX-2\u4f1a\u5f71\u54cd\u8840\u7ba1\u7684\u8212\u5f20\u8c03\u8282\uff0c\u589e\u52a0\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98ce\u9669\u3002<\/p>\n

2004\u5e74\uff0c\u7f57\u975e\u6614\u5e03\u56e0\u6b64\u88ab\u5f3a\u5236\u64a4\u5e02\u3002<\/p>\n

\u8fd9\u4ef6\u4e8b\u5f88\u80fd\u8bf4\u660e\u95ee\u9898\uff1a\u540c\u4e00\u6761\u751f\u5316\u8def\u5f84\uff0c\u5728\u4e0d\u540c\u7ec4\u7ec7\u91cc\u627f\u62c5\u4e0d\u540c\u7684\u89d2\u8272\u3002<\/p>\n

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